Buy Opzelura (ruxolitinib) online
What is Opzelura (ruxolitinib) for?
Buy Opzelura (ruxolitinib) online is a Janus kinase (JAK) inhibitor indicated for short-term and non-continuous treatment of mild to moderate eczema (atopic dermatitis) in non-immunocompromised (without weakened immune systems) people 12 and older whose disease is not well controlled with topical prescription therapies or when those therapies are not recommended.[1]
It is available in topical cream form, containing 1.5% ruxolitinib.[1]
How does Opzelura (ruxolitinib) work?
Ruxolitinib, the active ingredient in Opzelura, is a kinase inhibitor. This is a type of protein that can specifically block the enzymes JAK1 and JAK2, which are involved in the development of inflammation in the skin, itch, and skin barrier function.[2]
By blocking the activity of JAK1 and JAK2 in eczema, Opzelura can reduce and/or lessen the signs and symptoms of eczema by reducing itch, rash, and skin redness.[2]
Where has Opzelura (ruxolitinib) been approved?
Buy Opzelura (ruxolitinib) online was approved for the treatment of moderate to severe eczema in people aged 12 years and older by:
- The Food and Drug Administration (FDA), USA on Sept 21, 2021.[4]
Please note that this medicine may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval in a specific country feel free to contact our support team.
How is Opzelura (ruxolitinib) taken?
The standard dosage is:[1]
- A thin layer of cream applied twice a day to affected areas of the skin
Use Opzelura on up to 20% of your body. Do not use more than one 60 g tube per week.[1]
Stop using Opzelura once your eczema signs and symptoms (e.g., itch, rash, and redness) have resolved. If it does not improve within 8 weeks, you should talk to your treating doctor.[1]
Do not use Opzelura in combination with therapeutic biologics, other JAK inhibitors or potent immunosuppressants such as azathioprine or cyclosporine.[1]
Complete information about Opzelura (ruxolitinib) dosage and administration can be found in the official prescribing information listed in our references section.[1]
Note: Please consult with your treating doctor for personalised dosing.
Are there any known adverse reactions or side effects of Opzelura (ruxolitinib)?
Common adverse reactions
The most common side effects (≥1% of patients) listed in the prescribing information include:[1]
- Swelling of nasal passages
- Diarrhea
- Bronchitis
- Ear infection
- Increased eosinophil counts
- Urticaria
- Folliculitis
- Tonsillitis
- Runny nose
Serious adverse reactions
The serious adverse reactions listed in the prescribing information include:[1]
- Serious infections
- Major adverse cardiovascular events
- Clotting (thrombosis)
- Cancer and immune system problems
- All-cause mortality for patients taking JAK inhibitors orally (by mouth)
Use in a specific population
Before using Buy Opzelura (ruxolitinib) online , tell your treating doctor about all of your medical conditions, including if you:
- Have an infection
- Have or had tuberculosis (TB), or have been in close contact with someone who has TB
- Have had shingles (herpes zoster)
- Have or had hepatitis B or C
- Have had skin cancer in the past
- Are a current or past smoker
- Have or have had low white or red blood cell counts
- Have high levels of fat in your blood (high cholesterol or triglycerides)
- Are pregnant or planning to become pregnant. It is not known if this medicine will harm your unborn baby.
For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.[1]
References
1. Full prescribing information [FDA]: Opzelura (ruxolitinib) [PDF]
Incyte, Sep 2021
2. Ruxolitinib
Nationaleczema.org, cited Jan 2022
3. Incyte Announces U.S. FDA Approval of Opzelura™ (ruxolitinib) Cream, a Topical JAK Inhibitor, for the Treatment of Atopic Dermatitis (AD)
Incyte press release, Sep 2021
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